In the present study, the ethanol extract of Beta vulgaris (BV) roots were assessed for anxiogenic activity. The BV (50 and 100 mg/kg) administered intraperitoneally (i.p.) exhibited anxiogenic activity in elevated plus-maze (EPM) paradigm. In the EPM test, BV decreased the time spent by rat in the open arm and increase time spent and number of entries in closed arm. Further, the effect of diazepam (1 mg/kg i.p.), serotonin 5-HT3 receptor antagonist, ondansetron (1 mg/kg i.p) on the occupancy in open arm was significantly reduced by BV. Inhibition of anxiolytic activity of ondansetron (5-HT3 receptor antagonist) and diazepam (acting on gamma-aminobutyric acid (GABAA) receptor) suggests anxiogenic activity of BV.
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